KARISMA FACE Rh Collagen® | Injectable Collagen Biostimulator

KARISMA FACE Rh Collagen®

KARISMA FACE Rh Collagen® is an injectable bio-restitutive soft filler designed to support skin firmness, structure and collagen restoration through a unique combination of recombinant type I collagen, high-molecular-weight hyaluronic acid and carboxymethyl cellulose.

Designed for professional aesthetic practice, KARISMA FACE Rh Collagen® works differently from a conventional volumising dermal filler. Its formulation is focused on biorestitutive and regenerative skin support, with the manufacturer reporting stimulation of type I collagen production in human fibroblasts.

The formulation combines three principal components:

• R-polypeptide α1 chain of type I collagen
• High Molecular Weight Hyaluronic Acid
• Carboxymethyl Cellulose (CMC)

Together, these components provide a professional injectable option for practitioners looking beyond conventional volumisation towards collagen support, tissue quality and skin firmness.

RECOMBINANT TYPE I COLLAGEN

At the centre of the KARISMA formulation is the R-polypeptide α1 chain of type I collagen.

According to KARISMA, this patented recombinant collagen technology is synthesised by transgenic silkworm and secreted in the cocoon. The hydroxylated α1 chain acts as a precursor in endogenous collagen synthesis.

The manufacturer describes the recombinant collagen as having 99.9% similarity, 100% solubility at a molecular size of 100 kDa and immediate bioavailability due to its monofilament structure.

HIGH MOLECULAR WEIGHT HYALURONIC ACID

High-molecular-weight hyaluronic acid forms the second component of the formulation.

Hyaluronic acid is naturally present within the extracellular matrix and contributes to tissue hydration and extracellular matrix function.

Within the KARISMA formulation, the manufacturer identifies roles including tissue hydration, orientation of collagen fibres and regulation of cellular synthesis and differentiation.

CARBOXYMETHYL CELLULOSE

The third key component is Carboxymethyl Cellulose (CMC).

KARISMA describes its CMC as being of non-bacterial and non-animal origin.

Within the formulation, CMC acts as more than simply a carrier. The manufacturer reports inhibition of hyaluronidase activity, helping preserve endogenous hyaluronic acid, alongside slowing the activity of matrix metalloproteinases involved in type I collagen degradation.

BIO-RESTITUTIVE APPROACH

KARISMA FACE Rh Collagen® is positioned as a bio-restitutive injectable, rather than simply another product designed to add facial volume.

The manufacturer's approach focuses on supporting the biological components involved in skin structure and quality.

KARISMA reports that cellular stimulation from the formulation supports improvements in firmness and skin structure, with gradual visible improvement.

KEY BENEFITS

• Injectable recombinant type I collagen technology
• Contains R-polypeptide α1 chain of type I collagen
• High-molecular-weight hyaluronic acid
• Carboxymethyl cellulose
• Promotes type I collagen production in human fibroblasts
• Supports skin firmness and structure
• Bio-restitutive approach rather than conventional volumisation alone
• Class III injectable medical device
• Designed for professional aesthetic practice

IDEAL FOR

Collagen Biostimulation | Injectable Collagen | Regenerative Aesthetics | Skin Quality | Skin Firmness | Skin Laxity | Biostimulators | Professional Injectable Treatments | Aesthetic Clinics | Medical Aesthetics

PROFESSIONAL INFORMATION

KARISMA FACE Rh Collagen® is an injectable Class III medical device intended for professional use.